Biospectal leads in clinical research and validation of optical blood pressure technology, with over 15 years of development and testing. Below is a selection of our published research exploring the different aspects of software based, non-invasive optical blood pressure measurement.

Blood Pressure research journal

“Cuffless Blood Pressure in clinical practice: challenges, opportunities and current limits.”

Benoit Henrya, Maxime Merza, Harry Hoanga, Ghaith Abdulkarimb,c, Jedrek wosikd and Patrick Schoettker.
Taylor & Francis Blood Pressure 33, no.1 (January 2024)

Journal of Personalized Medicine JPM Logo

Smartphone-Based versus Non-Invasive Automatic Oscillometric Brachial Cuff Blood Pressure Measurements: A Prospective Method Comparison Volunteer Study.
Delmotte, Lila, Olivier Desebbe, Brenton Alexander, Karim Kouz, Sean Coeckelenbergh, Patrick Schoettker, Tuna Turgay, and Alexandre Joosten.
Journal of Personalized Medicine 14, no. 1 (January 2024): 15.

Accuracy of a smartphone application for blood pressure estimation in Bangladesh, South Africa, and Tanzania

Charles Festo, Valerie Vannevel, Hasmot Ali, Tigest Tamrat, Getrud J. Mollel, Tsakane Hlongwane, Kaniz A. Fahmida, Kelsey Alland, María Barreix, Hedieh Mehrtash, Ronaldo Silva, Soe Soe Thwin, Garrett Mehl, Alain B. Labrique, Honorati Masanja & Ӧzge Tunçalp
npj Digit. Med. 6, 69 (2023).

Blood Pressure research journal

Accuracy of blood pressure measurement across BMI categories using the OptiBP™ mobile application

Mary Caillat, Jean Degott, Arlene Wuerzner, Martin Proençain, Guillaume Bonnier, Jean-François Knebel, Chloé Stoll, Urvan Christen, Virginie Durgnat, Gregory Hofmann, Michel Burnier, Grégoire Wuerzner & Patrick Schoettker (2022) Accuracy of blood pressure measurement across BMI categories using the OptiBP™ mobile application, Blood Pressure, 31:1, 288-296, DOI: 10.1080/08037051.2022.2132214

Evaluation of a novel optical smartphone blood pressure application: a method comparison study against invasive arterial blood pressure monitoring in intensive care unit patients

Desebbe, O., Anas, C., Alexander, B. et al.  BMC Anesthesiol. 2022 Aug 15; 259 (22): doi: 0.1186/s12871-022-01797-0

Blood pressure measurements with the OptiBP smartphone app validated against reference auscultatory measurements. 

Schoettker P, Degott J, Hofmann G, Proença M, Bonnier G, Lemkaddem A, Lemay M, Schorer R, Christen U, Knebel JF, Wuerzner A, Burnier M, Wuerzner G.

Sci Rep. 2020 Oct 20;10(1):17827. doi: 10.1038/s41598-020-74955-4.

PMID: 33082436 Free PMC article.

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy. 

Squair JW, Berney M, Castro Jimenez M, Hankov N, Demesmaeker R, Amir S, Paley A, Hernandez-Charpak S, Dumont G, Asboth L, Allenbach G, Becce F, Schoettker P, Wuerzner G, Bally JF, Courtine G, Bloch J.

N Engl J Med. 2022 Apr 7;386(14):1339-1344. doi: 10.1056/NEJMoa2112809.

PMID: 35388667

A novel smartphone app for blood pressure measurement: a proof-of-concept study against an arterial catheter

Hofmann, G., Proença, M., Degott, J. et al. J Clin Monit Comput. 2022 Jun 21. doi: 10.1007/s10877-022-00886-2. Online ahead of print.

Evaluation of a new smartphone optical blood pressure application (OptiBPM™) in the post-anesthesia care unit: a method comparison study against the non-invasive automatic oscillometric brachial cuff as the reference method. 

Desebbe O, El Hilali M, Kouz K, Alexander B, Karam L, Chirnoaga D, Knebel JF, Degott J, Schoettker P, Michard F, Saugel B, Vincent JL, Joosten A.

J Clin Monit Comput. 2022 Jan 3. doi: 10.1007/s10877-021-00795-w. Online ahead of print.

PMID: 34978654

Evaluation of a novel mobile phone application for blood pressure monitoring: a proof of concept study. 

Desebbe O, Tighenifi A, Jacobs A, Toubal L, Zekhini Y, Chirnoaga D, Collange V, Alexander B, Knebel JF, Schoettker P, Joosten A.

J Clin Monit Comput. 2021 Aug 18. doi: 10.1007/s10877-021-00749-2. Online ahead of print.

PMID: 34409513


Smartphone based blood pressure measurement: accuracy of the OptiBP mobile application according to the AAMI/ESH/ISO universal validation protocol. 

Degott J, Ghajarzadeh-Wurzner A, Hofmann G, Proença M, Bonnier G, Lemkaddem A, Lemay M, Christen U, Knebel JF, Durgnat V, Burnier M, Wuerzner G, Schoettker P.

Blood Press Monit. 2021 Dec 1;26(6):441-448. doi: 10.1097/MBP.0000000000000556.

PMID: 34139747 Free PMC article.

Machine Learning Approaches For Improved Continuous, Non-occlusive Arterial Pressure Monitoring Using Photoplethysmography. 

Jorge J, Proenca M, Aguet C, Van Zaen J, Bonnier G, Renevey P, Lemkaddem A, Schoettker P, Lemay M.

Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:910-913. doi: 10.1109/EMBC44109.2020.9176512.

PMID: 33018132


Automated Pulse Oximeter Waveform Analysis to Track Changes in Blood Pressure During Anesthesia Induction: A Proof-of-Concept Study. 

Ghamri Y, Proença M, Hofmann G, Renevey P, Bonnier G, Braun F, Axis A, Lemay M, Schoettker P.

Anesth Analg. 2020 May;130(5):1222-1233. doi: 10.1213/ANE.0000000000004678.

PMID: 32287129 Clinical Trial.

Journal of Intensive Care

Is your smartphone the future of physiologic monitoring? 

Michard F, Barrachina B, Schoettker P.

Intensive Care Med. 2019 Jun;45(6):869-871. doi: 10.1007/s00134-018-5419-y. Epub 2018 Oct 19.

PMID: 30341565 No abstract available.